Book excerpt: This R Statistics book provides a solid step-by-step practical guide to statistical inference for comparing groups means using the R software. Additionally, we developed an R package named rstatix, which provides a simple and intuitive pipe-friendly framework, coherent with the `tidyverse` design philosophy, for computing the most common R statistical analyses, including t-test, Wilcoxon test, ANOVA, Kruskal-Wallis and correlation analyses, outliers identification and more. This book is designed to get you doing the statistical tests in R as quick as possible. The book focuses on implementation and understanding of the methods, without having to struggle through pages of mathematical proofs. You will be guided through the steps of summarizing and visualizing the data, checking the assumptions and performing statistical tests in R, interpreting and reporting the results. The main parts of the book include: PART I. Statistical tests and assumptions for the comparison of groups means; PART II. comparing two means (t-test, Wilcoxon test, Sign test); PART III. comparing multiple means (ANOVA - Analysis of Variance for independent measures, repeated measures ANOVA, mixed ANOVA, ANCOVA and MANOVA, Kruskal-Wallis test and Friedman test).