Book excerpt: This book, Psychological Support by Cognitive Behavioral Therapy (CBT) for Lissencephaly, was born out of the need to address the complex emotional and psychological challenges faced by individuals and families affected by lissencephaly, a rare but profoundly impactful neurological condition. Lissencephaly, characterized by an absence of normal brain folds, often brings a unique array of physical, developmental, and emotional challenges. These challenges extend beyond the individual, affecting families, caregivers, and even communities. This book aims to provide a comprehensive guide to cognitive behavioral therapy (CBT) and its application for supporting mental health and resilience within this context. Each section has been crafted with a dual purpose: to offer a thorough understanding of the biological, genetic, and psychological aspects of lissencephaly and to introduce actionable, evidence-based CBT strategies tailored to the specific needs arising from this condition. This book explores essential foundations, from understanding genetic and epigenetic influences to practical therapeutic approaches, coping mechanisms, and tools for pain management. Given the chronic and often unpredictable nature of lissencephaly, mental health support becomes critical. While we often address physical symptoms and medical treatments, emotional health, too, requires a compassionate, structured approach. CBT offers a powerful method for navigating the internal and external realities faced by those affected. It enables individuals to confront negative thinking patterns, build resilience, and find meaning even amid difficult circumstances. Whether you are a healthcare professional, caregiver, family member, or individual seeking understanding, it is my hope that this book provides practical and compassionate insights. As you turn these pages, may you find tools that empower, strategies that support healing, and encouragement to foster resilience. Together, we can create a support system that helps individuals affected by lissencephaly lead lives filled with hope, strength, and dignity.