Book excerpt: Fully revised and updated, the third edition of this full-color chart collects many of the most clinically useful tables, algorithms, and other items from the Red Book, 33rd Edition and presents them in an enlarged, enhanced colorized format that is lightweight, portable, and easy to navigate. Additionally, new tables have been created exclusively for this chart, synthesizing important clinical information from the Red Book text. Topics include: Staphylococcal Infections Streptococcal Infections COVID-19 and Multisystem Inflammatory Syndrome in Children (MIS-C) Diarrheal Infections Immunizations Antibiotic Prophylaxis Immune Globulin Kawasaki Disease Tuberculosis Lyme Disease Varicella-Zoster Fungal Infections Genital and Neonatal Herpes Syphilis HIV Immunocompromised Children and Adolescents