Book excerpt: The COVID-19 pandemic has dramatically changed social interactions. Social distancing policies, lockdowns, and mandatory quarantines have accelerated the technological mediation of communication (e.g. AI-mediated communication, computer-mediated communication) on an unprecedented scale, willingly or otherwise. Many physical activities such as office work, education, and conferences have had to be performed in the online space through social media apps, the metaverse or specialized programs on mobile phones or laptops as part of pandemic control efforts. As a result, digitally mediated channels have become critical for information acquisition and communication across a wide spectrum of human activities such as education, social interaction, entertainment, and commercial activities. Human beings are increasingly reliant on non-human agents, including social media, Artificial Intelligence (AI) powered tools, or smartphone mobile devices for most routine activities, professional communication, and social interactions. As scientific understanding of COVID-19 improves, pandemic restrictions are gradually loosening. However, it remains to be seen whether the pandemic communication paradigm characterized by heavy technological mediation and reliance on non-human agents will also gradually decline, or will the paradigm shift become deeply entrenched with further acceleration of dependency on technological mediation and non-human agents.