Book excerpt: Overviews of biochemical, genetic, and molecular perspectives of plant-insect interactions with added emphasis on bioinformatic, genomic, and transcriptome analysis are comprehensively treated in this book. It presents the agro-ecological and evolutionary aspects of plant-insect interactions with an exclusive focus on the climate change effect on the resetting of plant-insect interactions. A valuable resource for biotechnologists, entomologists, agricultural scientists, and policymakers, the book includes theoretical aspects as a base toward real-world applications of holistic integrated pest management in agro-ecosystems.