Book excerpt: This book offers conceptual and empirical insights from economic geography to explore how uncertainties, crises, and risks, shape, reshape, and ultimately transform the spatial arrangements of companies and regions. This book provides valuable insights into the evolving landscape of economic interactions amidst contemporary challenges. It explores concepts such as global value chains, global production networks, regional resilience, and the impact of crises, risks, and uncertainties on spatial economic patterns. Case studies from various regions, nations, and industries, including lesser researched sectors such as medical technology and the restaurant and bar industry offer tangible and real-world manifestations of these dynamics. Through its comprehensive coverage and interdisciplinary approach, this book equips readers with practical knowledge applicable to academia and real-world contexts. It offers a deeper understanding of the complex interplay between economic geography and contemporary challenges at a variety of levels. The book provides valuable perspectives for academics, practitioners, and policy makers in the fields of Economic Geography, Regional Studies, Political Sciences, Economic Sociology, Economics, and International Business Studies.