Search Results

The Changing Faces of Glutathione, a Cellular Protagonist

Download or Read eBook The Changing Faces of Glutathione, a Cellular Protagonist PDF written by Alfonso Pompella and published by Frontiers Media SA. This book was released on 2015-07-17 with total page 144 pages. Available in PDF, EPUB and Kindle.
The Changing Faces of Glutathione, a Cellular Protagonist
Author :
Publisher : Frontiers Media SA
Total Pages : 144
Release :
ISBN-10 : 9782889195954
ISBN-13 : 2889195953
Rating : 4/5 (54 Downloads)

Book Synopsis The Changing Faces of Glutathione, a Cellular Protagonist by : Alfonso Pompella

Book excerpt: Glutathione (GSH) has been described for a long time just as a defensive reagent against the action of toxic xenobiotics (drugs, pollutants, carcinogens), both directly and as a cofactor for GSH transferases. As a prototype antioxidant, it has been involved in cell protection from the noxious effect of excess oxidant stress, both directly and as a cofactor of glutathione peroxidases. In addition, it has long been known that GSH is capable of forming disulfide bonds with cysteine residues of proteins, and the relevance of this mechanism ("S-glutathionylation") in regulation of protein function has been well documented in a number of research fields. Rather paradoxically, it has also been highlighted that GSH—and notably its catabolites, as originated by metabolism by gamma-glutamyltransferase—can promote oxidative processes, by participating in metal ion-mediated reactions eventually leading to formation of reactive oxygen species and free radicals. Also, a fundamental role of GSH has been recognized in the storage and transport of nitric oxide (NO), in the form of S-nitrosoglutathione (GSNO). The significance of GSH as a major factor in regulation of cell life, proliferation, and death, can be regarded as the integrated result of all these roles, as well as of more which are emerging in diverse fields of biology and pathophysiology. Against this background, modulation of GSH levels and GSH-related enzyme activities represents a fertile field for experimental pharmacology in numerous and diverse perspectives of animal, plant and microbiologic research. This research topic includes 14 articles, i.e. 4 Opinion Articles, 6 Reviews, and 4 Original Research Articles. The contributions by several distinguished research groups, each from his own standpoint of competence and expertise, provide a comprehensive and updated view over the diverse roles, the changing faces of GSH and GSH-related enzymes in cell’s health, disease and death.


The Changing Faces of Glutathione, a Cellular Protagonist Related Books

The Changing Faces of Glutathione, a Cellular Protagonist
Language: en
Pages: 144
Authors: Alfonso Pompella
Categories: Pharmacology
Type: BOOK - Published: 2015-07-17 - Publisher: Frontiers Media SA

DOWNLOAD EBOOK

Glutathione (GSH) has been described for a long time just as a defensive reagent against the action of toxic xenobiotics (drugs, pollutants, carcinogens), both
Index Medicus
Language: en
Pages: 1504
Authors:
Categories: Medicine
Type: BOOK - Published: 2004 - Publisher:

DOWNLOAD EBOOK

Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Glutathione
Language: en
Pages: 411
Authors: Leopold Flohe
Categories: Medical
Type: BOOK - Published: 2018-08-29 - Publisher: CRC Press

DOWNLOAD EBOOK

This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione bio
Oxidative Stress in Cancer Biology and Therapy
Language: en
Pages: 465
Authors: Douglas R. Spitz
Categories: Science
Type: BOOK - Published: 2011-11-25 - Publisher: Springer Science & Business Media

DOWNLOAD EBOOK

During the last 30 years it has become clearly evident that oxidative stress and free radical biology play key roles in carcinogenesis, cancer progression, canc
Oxidants in Biology
Language: en
Pages: 324
Authors: Giuseppe Valacchi
Categories: Medical
Type: BOOK - Published: 2008-06-06 - Publisher: Springer Science & Business Media

DOWNLOAD EBOOK

Oxidants, like other aspects of life, involves tradeoffs. Oxidants, whether intentionally produced or by-products of normal metabolism can either mediate a vari
Scroll to top