Book excerpt: The Cloud in IoT-enabled Spaces addresses major issues and challenges in IoT-based solutions proposed for the Cloud. It paves the way for IoT-enabled spaces in the next generation cloud computing paradigm and opens the door for further innovative ideas. Topics include Cloud-based optimization in the IoT era, scheduling and routing, medium access, data caching, secure access, uncertainty, home automation, machine learning in wearable devices, energy monitoring, and plant phenotyping in farming. Smart spaces are solutions where Internet of Things (IoT)-enabling technologies have been employed towards further advances in the lifestyle. It tightly integrates with the existing Cloud infrastructure to impact several fields in academia and industry. The Cloud in IoT-enabled Spaces provides an overview of the issues around small spaces and proposes the most up-to-date alternatives and solutions. The objective is to pave the way for IoT-enabled spaces in the next-generation Cloud computing and open the door for further innovative ideas.