Book excerpt: The functionality of modern structural, mechanical and electrical or electronic systems depends on their ability to perform under uncertain conditions. Consideration of uncertainties and their effect on system behavior is an essential and integral part of defining systems. In eleven chapters, leading experts present an overview of the current state of uncertainty modeling, analysis and design of large systems in four major areas: finite and boundary element methods (common structural analysis techniques), fatigue, stability analysis, and fault-tolerant systems. The content of this book is unique; it describes exciting research developments and challenges in emerging areas, and provide a sophisticated toolbox for tackling uncertainty modeling in real systems.