Book excerpt: Artificial intelligence (AI)-based solutions are slowly making their way into our daily lives, integrating with our processes to enhance our lifestyles. This is major a technological component regarding the development of autonomous vehicles (AVs). However, as of today, no existing, consumer ready AV design has reached SAE Level 5 automation or fully integrates with the driver. Unsettled Issues in Vehicle Autonomy, AI and Human-Machine Interaction discusses vital issues related to AV interface design, diving into speech interaction, emotion detection and regulation, and driver trust. For each of these aspects, the report presents the current state of research and development, challenges, and solutions worth exploring. Click here to access the full SAE EDGETM Research Report portfolio. https://doi.org/10.4271/EPR2021010