Book excerpt: The COVID-19 pandemic has disrupted the economies, public health, and medical care systems. It is also shaping the future of work. The pandemic has normalized various trends about work, with significant implications for enterprises, employee health, and wellbeing. Internationally, employers, government agencies, public health agencies, trade unions, and professional associations have dealt with maintaining economic activity while keeping workers safe and healthy. The pandemic has emphasized the importance of work in shaping population health and wellbeing. This perspective implies a multilevel system framework to aid in understanding the complex and diverse interactions of factors impacting worker health and wellbeing. It also implies how trending changes in employment and working conditions have been accelerated by the pandemic. Government organizations concerned with population health and wellbeing, and economic activity must expand their capability to screen, assess, and react to these trends after the pandemic. Additionally, integrated enterprise and workplace-based approaches that consider the interactions among these multidimensional drivers will build organization and worker resilience to navigate the continual changes in work and worker safety, health, and wellbeing in a post-pandemic world.